曹帅
博士，教授（四级），课题组组长（PI），硕士/博士导师，博士后合作导师
邮箱：caos135@nwafu.edu.cn
通讯地址：陕西杨凌，西北农林科技大学生命科学学院，712100
空余职位：招收推免生（校内外保研生/直博生），硕士/博士生，实习生（本科或硕士）；常年招聘相关领域博士后。
一、个人简介
曹帅，男，教授（PI），博士生导师。河南平舆人，本科毕业于东北师范大学生命科学学院（基地班），获生物科学理学学位；并推免进入南京农业大学攻读研究生学位，获作物遗传育种博士学位。2022年加入新加坡国立大学淡马锡生命科学实验室，任Research Fellow。2025年进入西北农林科技大学生命科学学院工作，任教授（四级），硕士/博士导师，博士后合作导师，课题组组长（PI）。长期从事植物进化、作物驯化育种的遗传及表观遗传学基础解析。2021年至今，以第一/主要作者在PNAS (2021)，Genome Biology (2022；2024)，Nature Communications (2025)，Trends in Plant Science (2024)，Plant Cell (2023)等中科院1区Top期刊发表多篇SCI论文（累计影响因子100+）。
二、研究兴趣及方向
1. 作物驯化的遗传及表观遗传学基础解析（涉及作物育种，物种进化，遗传学，表观遗传学，生物化学、细胞生物学，生物信息学，生物大数据，机器学习等众多生命科学学科）：以旱区作物为研究对象，基于自然及人工群体、多组学（生物大数据）技术，对作物野生种质资源优异等位基因或元件的遗传及表观遗传机制高效挖掘及精准调控位点鉴定；综合运用遗传学、生物化学、细胞生物学等多种手段探索功能基因和元件的作用机制；并利用基因编辑、远缘回交渐渗、基因组加倍等，拓宽栽培作物的遗传背景或从头驯化，从而进行作物品质及抗逆种质创新及育种。
2. 作物复杂基因组的表观遗传调控机制解析（涉及表观遗传学，遗传学，生物化学、细胞生物学，生物信息学，生物大数据，机器学习等众多学科）：以旱区作物为研究对象，基于突变体库、多组学（生物大数据）和基因编辑技术，对DNA甲基化和RNA甲基化的表观遗传调控通路关键基因进行功能解析；综合运用遗传学、生物化学、细胞生物学等多种手段探索表观遗传对下游基因的精细调控机理；结合性状筛选育种潜力基因，并利用基因编辑、表观遗传学技术等，进行作物品质及抗逆种质创新及育种。
平台及技术支持：除校超算平台外，实验室独立配备高性能CUPs/GPUs服务器HPC（256线程）。本实验室具备手搓各种组学实验建库、分析等一揽子技术服务（涵盖基于二代测序平台的DNAseq，如HiCseq/BASseq/16SrRNAseq/ChIPseq/DAPseq/BSseq等和各种RNAseq如mRNAseq/ncRNAseq/RIPseq/CLIPseq等；以及sn/scRNAseq，空间转录组分析；基于三代Oxford Nanopore和Pacbio平台数据分析、基因组组装及模型开发；并进行新组学技术开发等）和群体遗传与表观遗传研究（多组学与智慧育种）。常年欢迎业内专家学者、学生前来交流、合作。
三、教学与招生
表观遗传学（32学时，本科生/研究生），基因组学（32学时，本科生/研究生），生物大数据（32学时，研究生）等。
团队招收推免生（校内外保研生/直博生），硕士/博士生，实习生（本科或硕士）；常年招聘相关领域博士后。欢迎感兴趣同学直接将最新个人简历（含发表文章、获奖等信息）发送至PI邮箱：caos135@nwafu.edu.cn。
四、发表学术论文（https://orcid.org/0000-0001-5237-3827）：
代表性论文：
2025. Shuai Cao, Nunchanoke S, Lisha Shen*. Lactuca super-pangenome provides insights into lettuce genome evolution and domestication. Nature Communications (Accepted). (2024年中科院1区Top | 当年IF=15.7)
2024. Shuai Cao, Nunchanoke S, ... Sheng Fan, Lisha Shen*. DNA methylation variations underlie lettuce domestication and divergence. Genome Biology, 25(0):158. (2024年中科院1区Top | 当年IF=10.1)
2024. Shuai Cao and Z. Jefrey Chen*. Transgenerational epigenetic inheritance during plant domestication and breeding. Trends in Plant Science, 29(11):P1203-1223. (封面, 深度长文 , 2024年中科院1区Top | 当年IF=17.3)
2024. Shuai Cao, Nunchanoke S, Lisha Shen*. Gapless genome assembly and epigenetic profiles reveal gene regulation of whole-genome triplication in lettuce. GigaScience, 13(0):1-16. (2024年中科院2区 | 当年IF=11.8)
2024. Shuai Cao#, Huanhuan Zhang#, ... Yi Sun, Z. Jefrey Chen*. Cytoplasmic genome contributions to domestication and improvement of modern maize. BMC Biology, 22(0):64. (2023年中科院1区 | 当年IF=5.4)
2023. Shuai Cao#, Kai Chen#, ... Jianlong Xu*, Qingxin Song*. Asymmetric variation of DNA methylation during domestication and de-domestication of rice. Plant Cell, 35 (9): 3429-3443. (2023年中科院1区Top | 当年IF=11.3; 专家点评：Dr. Sara Lopez-Gomollon, Plant Cell, 2023)
2022. Shuai Cao, Longfei Wang, ... Qingxin Song, Z. Jeffrey Chen*. Transgenerational DNA methylation depends on 24-nt siRNA in maize. Genome Biology, 23(0):53. (2022年中科院1区Top | 当年IF=17.3)
其他合作论文：
2021. Longfei Wang, Shuai Cao, Peitong Wang, Kening Lu, Qingxin Song, Fangjie Zhao, Z. Jeffrey Chen*. DNA hypomethylation in tetraploid rice potentiates stress-responsive gene expression for salt tolerance. PNAS, 118(13):e2023981118.
2021. Longfei Wang, Gonghong Jia, Xinyu Jiang, Shuai Cao, Z. Jeffrey Chen, Qingxin Song*. Altered chromatin architecture and gene expression during polyploidization and domestication of Soybean. Plant Cell, 33(5):1430-1446.
2015. Ying Wu, Yue Sun, Kun Shen, Shuai Sun, Jie Wang, Tingting Jiang, Shuai Cao, Samuel Manthi Josiah, Jinsong Pang, Xiuyun Lin, Bao Liu*. Immediate genetic and epigenetic changes in F1 hybrid sparented by species with divergent genomes in the rice genus (Oryza). Plos One,10(7):e0132911.
注：*代表通讯作者；#代表同等贡献。
五、联系方式
邮箱：caos135@nwafu.edu.cn
地址：陕西杨凌，西北农林科技大学生命科学学院，712100
更新于2025年07月
英文简介（CV）
Shuai Cao
Ph.D., Full Professor, Principal Investigator (PI), Supervisor of Doctorate Candidates
Email：caos135@nwafu.edu.cn
Mailing address: College of Life Sciences, Northwes tA&F University, Yangling, Shaanxi 712100, P.R.China.
1. Introduction
Prof. Cao received his B.S. in biological at Northeast Normal University, and Ph.D. in Agronomy (Crop Genetics and Breeding) at Nanjing Agricultural University. Following a Research Fellow position, he joined the faculty at Temasek Life Sciences Laboratory, National University of Singapore. In 2025, he joined the faculty of College of Life Science, Northwest Agriculture and Forestry University and was promoted to Full Professor and Principal Investigator. 2021, research had been published on PNAS, Genome Biology, Nature Communications, Trends in Plant Science, Plant Cell etc. (Total IF over 100).
2. Research Interests
Genetics and epigenetics of crop domestication and breeding (related to crop breeding, evolution, genetics, epigenetics, cell biology, bioinformation, bigdata, machine learning, etc), focus on natural and artificial population, use multi-omics for mining functional genes or regulator elements derived from wild relatives of crops; and then integrated genetics, epigenetics, biochemistry, cell biology, etc for investigation of their molecular mechanism; further use gene editing, backcrossing, genome double, etc for increasing the genetic variation of cultivated crops or de novo domestication, finally innovating germplasm and breeding on crop quality and resilience.
3. Teaching and Course
Epigenetics (Undergraduate/Graduate course), Genomics (Undergraduate/Graduate course), Biological Big Data (Graduate course …),
4. Positions
We are seeking some highly motivated individuals for Master Program (2-3 positions/year), Ph.D. Program (1-2 positions/year), Postdoctoral Position (1-2 opening positions), Assistant Research (1-2 opening positions) to join our dynamic research team. Requirements: Degree in Biology/Medicine/Agronomy in Life Science, Bigdata/AI in Computer Science or related fields. Interested individuals should send their Curriculum Vitae with a list of publications to: caos135@nwafu.edu.cn.
5. Publish(https://orcid.org/0000-0001-5237-3827)：
Selected Published (#Co-first authors; *Co-corresponding authors)：
2025. Shuai Cao, Nunchanoke S, Lisha Shen*. Lactuca super-pangenome provides insights into lettuce genome evolution and domestication. Nature Communications (Accepted). (IF2025=15.7)
2024. Shuai Cao, Nunchanoke S, Ping Li, Sheng Fan, and Lisha Shen*. DNA methylation variations underlie lettuce domestication and divergence. Genome Biology, 25(0):158. (IF2024=10.1)
2024. Shuai Cao and Z. Jefrey Chen*. Transgenerational epigenetic inheritance during plant domestication and breeding. Trends in Plant Science, 29(11):P1203-1223. (Cover Story, Feature Review, IF2024=17.3)
2024. Shuai Cao, Nunchanoke S and Lisha Shen*. Gapless genome assembly and epigenetic profiles reveal gene regulation of whole-genome triplication in lettuce. GigaScience, 13(0):1-16. (IF2024=11.8)
2024. Shuai Cao#, Huanhuan Zhang#, Yang Liu, Yi Sun and Z. Jefrey Chen*. Cytoplasmic genome contributions to domestication and improvement of modern maize. BMC Biology, 22(0):64. (IF2023=5.4)
2023. Shuai Cao#, Kai Chen#, Kening Lu, Shiting Chen, Xiyu Zhang, Congcong Shen, Shuangbin Zhu, Yanan Niu, Longjiang Fan, Z. Jeffrey Chen*, Jianlong Xu*, Qingxin Song*. Asymmetric variation of DNA methylation during domestication and de-domestication of rice. Plant Cell, 35 (9): 3429-3443. (IF2023=11.3; Featured by Dr. Sara Lopez-Gomollon, Plant Cell, 2023)
2022. Shuai Cao, Longfei Wang, Tone Han, Wenxue Ye, Yang Liu, Yi Sun, Stephen P. Moose, Qingxin Song, Z. Jeffrey Chen*. Transgenerational DNA methylation depends on 24-nt siRNA in maize. Genome Biology, 23(0):53. (IF2022=17.3)
Other Co-authored Papers:
2021. Longfei Wang, Shuai Cao, Peitong Wang, Kening Lu, Qingxin Song, Fangjie Zhao, Z. Jeffrey Chen*. DNA hypomethylation in tetraploid rice potentiates stress-responsive gene expression for salt tolerance. PNAS, 118(13):e2023981118.
2021. Longfei Wang, Gonghong Jia, Xinyu Jiang, Shuai Cao, Z. Jeffrey Chen, Qingxin Song*. Altered chromatin architecture and gene expression during polyploidization and domestication of Soybean. Plant Cell, 33(5):1430-1446.
2015. Ying Wu, Yue Sun, Kun Shen, Shuai Sun, Jie Wang, Tingting Jiang, Shuai Cao, Samuel Manthi Josiah, Jinsong Pang, Xiuyun Lin, Bao Liu*. Immediate genetic and epigenetic changes in F1 hybrids parented by species with divergent genomes in the rice genus (Oryza). Plos One, 10(7):e0132911.
2014. Huan Wang, Xiuyun Lin, Shuai Cao, Cunwu Yang*. Alkali tolerance in rice (Oryza sativa L.):growth, photosynthesis nitrogen metabolism and ion homeostasis. Photosynthetica, 53 (1): 55-65.
Updated@2025